node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKB1 | DHR2 | YGL019W | YKL078W | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | 0.921 |
CKB1 | ENP1 | YGL019W | YBR247C | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family | 0.908 |
CKB1 | HAS1 | YGL019W | YMR290C | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles | 0.900 |
CKB1 | IMP4 | YGL019W | YNL075W | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs | 0.998 |
CKB1 | KRR1 | YGL019W | YCL059C | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family | 0.991 |
CKB1 | SLX9 | YGL019W | YGR081C | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | Ribosome biogenesis protein SLX9; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant | 0.991 |
CKB1 | TSR1 | YGL019W | YDL060W | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | Ribosome biogenesis protein TSR1; Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily | 0.901 |
CKB1 | UTP18 | YGL019W | YJL069C | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats | 0.979 |
CKB1 | UTP5 | YGL019W | YDR398W | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | U3 small nucleolar RNA-associated protein 5; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP5 family | 0.782 |
CKB1 | UTP6 | YGL019W | YDR449C | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | Snorna-binding rrna-processing protein utp6; Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA | 0.998 |
DHR2 | CKB1 | YKL078W | YGL019W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases | 0.921 |
DHR2 | ENP1 | YKL078W | YBR247C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family | 0.998 |
DHR2 | HAS1 | YKL078W | YMR290C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles | 0.994 |
DHR2 | IMP4 | YKL078W | YNL075W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs | 0.993 |
DHR2 | KRR1 | YKL078W | YCL059C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family | 0.962 |
DHR2 | SLX9 | YKL078W | YGR081C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Ribosome biogenesis protein SLX9; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant | 0.999 |
DHR2 | TSR1 | YKL078W | YDL060W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Ribosome biogenesis protein TSR1; Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily | 0.955 |
DHR2 | UTP18 | YKL078W | YJL069C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats | 0.996 |
DHR2 | UTP5 | YKL078W | YDR398W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | U3 small nucleolar RNA-associated protein 5; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP5 family | 0.993 |
DHR2 | UTP6 | YKL078W | YDR449C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Snorna-binding rrna-processing protein utp6; Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA | 0.995 |