node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACF2 | ACT1 | YLR144C | YFL039C | Endo-1,3(4)-beta-glucanase 2; Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress; Belongs to the glycosyl hydrolase 81 family. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.404 |
ACF2 | LSB1 | YLR144C | YGR136W | Endo-1,3(4)-beta-glucanase 2; Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress; Belongs to the glycosyl hydrolase 81 family. | LAS seventeen-binding protein 1; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication. | 0.667 |
ACT1 | ACF2 | YFL039C | YLR144C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Endo-1,3(4)-beta-glucanase 2; Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress; Belongs to the glycosyl hydrolase 81 family. | 0.404 |
ACT1 | BBC1 | YFL039C | YJL020C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | 0.808 |
ACT1 | BZZ1 | YFL039C | YHR114W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins. | 0.849 |
ACT1 | LAS17 | YFL039C | YOR181W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches. | 0.997 |
ACT1 | LSB1 | YFL039C | YGR136W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | LAS seventeen-binding protein 1; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication. | 0.663 |
ACT1 | LTE1 | YFL039C | YAL024C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Guanine nucleotide exchange factor LTE1; Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures. | 0.543 |
ACT1 | MYO3 | YFL039C | YKL129C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Myosin-3; One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.891 |
ACT1 | PIN3 | YFL039C | YPR154W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | [PSI+] inducibility protein 3; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication. | 0.637 |
ACT1 | RSP5 | YFL039C | YER125W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome; Belongs to the RSP5/NEDD4 family. | 0.735 |
BBC1 | ACT1 | YJL020C | YFL039C | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.808 |
BBC1 | BZZ1 | YJL020C | YHR114W | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins. | 0.996 |
BBC1 | LAS17 | YJL020C | YOR181W | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches. | 0.988 |
BBC1 | LSB1 | YJL020C | YGR136W | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | LAS seventeen-binding protein 1; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication. | 0.957 |
BBC1 | MYO3 | YJL020C | YKL129C | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | Myosin-3; One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.981 |
BBC1 | PIN3 | YJL020C | YPR154W | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | [PSI+] inducibility protein 3; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication. | 0.937 |
BZZ1 | ACT1 | YHR114W | YFL039C | SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.849 |
BZZ1 | BBC1 | YHR114W | YJL020C | SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins. | Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches. | 0.996 |
BZZ1 | LAS17 | YHR114W | YOR181W | SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins. | Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches. | 0.999 |