| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HIP1 | MAY24 | YGR191W | YPR153W | High-affinity histidine permease; also involved in the transport of manganese ions. | Uncharacterized protein YPR153W; Protein of unknown function. | 0.501 |
| HIP1 | MPT5 | YGR191W | YGL178W | High-affinity histidine permease; also involved in the transport of manganese ions. | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | 0.492 |
| HIP1 | MUP1 | YGR191W | YGR055W | High-affinity histidine permease; also involved in the transport of manganese ions. | High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; To yeast low affinity methionine permease (MUP3). | 0.504 |
| HIP1 | PUF4 | YGR191W | YGL014W | High-affinity histidine permease; also involved in the transport of manganese ions. | Pumilio homology domain family member 4; Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors. | 0.502 |
| HIP1 | SAR1 | YGR191W | YPL218W | High-affinity histidine permease; also involved in the transport of manganese ions. | ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics. | 0.527 |
| HIP1 | SHR3 | YGR191W | YDL212W | High-affinity histidine permease; also involved in the transport of manganese ions. | Secretory component protein SHR3; Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface. | 0.983 |
| HIP1 | SLA2 | YGR191W | YNL243W | High-affinity histidine permease; also involved in the transport of manganese ions. | Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo; Belongs to the SLA2 family. | 0.649 |
| HIP1 | SWP82 | YGR191W | YFL049W | High-affinity histidine permease; also involved in the transport of manganese ions. | SWI/SNF global transcription activator complex subunit SWP82; Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions; Belongs to the RSC7/SWP82 family. SWP82 subfamily. | 0.541 |
| HIP1 | VPS24 | YGR191W | YKL041W | High-affinity histidine permease; also involved in the transport of manganese ions. | Vacuolar protein-sorting-associated protein 24; One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway. | 0.507 |
| HIP1 | YGR190C | YGR191W | YGR190C | High-affinity histidine permease; also involved in the transport of manganese ions. | Putative uncharacterized protein YGR190C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W. | 0.622 |
| MAY24 | HIP1 | YPR153W | YGR191W | Uncharacterized protein YPR153W; Protein of unknown function. | High-affinity histidine permease; also involved in the transport of manganese ions. | 0.501 |
| MPT5 | HIP1 | YGL178W | YGR191W | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | High-affinity histidine permease; also involved in the transport of manganese ions. | 0.492 |
| MPT5 | PUF4 | YGL178W | YGL014W | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | Pumilio homology domain family member 4; Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors. | 0.901 |
| MPT5 | SAR1 | YGL178W | YPL218W | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics. | 0.517 |
| MUP1 | HIP1 | YGR055W | YGR191W | High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; To yeast low affinity methionine permease (MUP3). | High-affinity histidine permease; also involved in the transport of manganese ions. | 0.504 |
| PUF4 | HIP1 | YGL014W | YGR191W | Pumilio homology domain family member 4; Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors. | High-affinity histidine permease; also involved in the transport of manganese ions. | 0.502 |
| PUF4 | MPT5 | YGL014W | YGL178W | Pumilio homology domain family member 4; Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors. | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | 0.901 |
| SAR1 | HIP1 | YPL218W | YGR191W | ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics. | High-affinity histidine permease; also involved in the transport of manganese ions. | 0.527 |
| SAR1 | MPT5 | YPL218W | YGL178W | ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics. | Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity. | 0.517 |
| SAR1 | SHR3 | YPL218W | YDL212W | ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics. | Secretory component protein SHR3; Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface. | 0.489 |
