| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACK1 | FYV8 | YDL203C | YGR196C | Activator of C kinase protein 1; Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.793 |
| ACK1 | OST6 | YDL203C | YML019W | Activator of C kinase protein 1; Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; Belongs to the OST3/OST6 family. | 0.863 |
| ACK1 | RGD1 | YDL203C | YBR260C | Activator of C kinase protein 1; Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria. | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization. | 0.904 |
| CMR2 | FYV8 | YOR093C | YGR196C | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.699 |
| CWH41 | FYV8 | YGL027C | YGR196C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.942 |
| CWH41 | OST6 | YGL027C | YML019W | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; Belongs to the OST3/OST6 family. | 0.999 |
| CWH41 | RGD1 | YGL027C | YBR260C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization. | 0.789 |
| CWH41 | ROT2 | YGL027C | YBR229C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. | 0.997 |
| CWH41 | YDR524W-C | YGL027C | YDR524W-C | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | Uncharacterized protein YDR524W-C; Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin. | 0.801 |
| FYV8 | ACK1 | YGR196C | YDL203C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Activator of C kinase protein 1; Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria. | 0.793 |
| FYV8 | CMR2 | YGR196C | YOR093C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents. | 0.699 |
| FYV8 | CWH41 | YGR196C | YGL027C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family. | 0.942 |
| FYV8 | MTC1 | YGR196C | YJL123C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1. | 0.781 |
| FYV8 | OST6 | YGR196C | YML019W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; Belongs to the OST3/OST6 family. | 0.755 |
| FYV8 | RGD1 | YGR196C | YBR260C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization. | 0.999 |
| FYV8 | ROT2 | YGR196C | YBR229C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family. | 0.809 |
| FYV8 | THI3 | YGR196C | YDL080C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Thiamine metabolism regulatory protein THI3; Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected. | 0.892 |
| FYV8 | YDR524W-C | YGR196C | YDR524W-C | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Uncharacterized protein YDR524W-C; Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin. | 0.801 |
| FYV8 | YGL214W | YGR196C | YGL214W | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | Putative uncharacterized protein YGL214W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C. | 0.747 |
| MTC1 | FYV8 | YJL123C | YGR196C | Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1. | Protein of unknown function; required for survival upon exposure to K1 killer toxin. | 0.781 |