Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
COS8Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; Belongs to the DUP/COS family. (381 aa)    
Predicted Functional Partners:
YHL045W
Putative protein of unknown function; not an essential gene.
   
  
 0.739
YHL049C
Uncharacterized protein YHL049C; Putative protein of unknown function.
   
  
 0.681
YFR057W
Uncharacterized protein YFR057W; Putative protein of unknown function.
   
  
 0.679
YHL044W
DUP240 protein YHL044W; Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern.
   
  
 0.667
RDS1
Regulator of drug sensitivity 1; Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide.
   
  
 0.651
YHL041W
Uncharacterized protein YHL041W; Putative protein of unknown function; conserved across S. cerevisiae strains.
   
  
 0.645
YHL046W-A
Putative uncharacterized protein YHL046W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C.
   
  
 0.645
YHL048C-A
Uncharacterized protein YHL048C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.
      
 0.633
YHL050C
Uncharacterized protein YHL050C; Putative protein of unknown function; potential Cdc28p substrate.
   
  
 0.613
SEO1
Probable transporter SEO1; Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide.
   
  
 0.597
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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