node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COG7 | ECM12 | YGL005C | YHR021W-A | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.538 |
COG7 | MFM1 | YGL005C | YPL060W | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. | 0.423 |
ECM12 | COG7 | YHR021W-A | YGL005C | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments. | 0.538 |
ECM12 | FYV7 | YHR021W-A | YLR068W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | 0.602 |
ECM12 | HMS1 | YHR021W-A | YOR032C | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant. | 0.444 |
ECM12 | LCP5 | YHR021W-A | YER127W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | 0.596 |
ECM12 | MCH2 | YHR021W-A | YKL221W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.538 |
ECM12 | MFM1 | YHR021W-A | YPL060W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family. | 0.690 |
ECM12 | NGL3 | YHR021W-A | YML118W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.760 |
ECM12 | PIG2 | YHR021W-A | YIL045W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | GSY2-interacting protein PIG2; Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication. | 0.552 |
ECM12 | RCK1 | YHR021W-A | YGL158W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Serine/threonine-protein kinase RCK1; Protein kinase involved in oxidative stress response; promotes pseudohyphal growth via activation of Ubp3p phosphorylation; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication. | 0.520 |
ECM12 | SNO1 | YHR021W-A | YMR095C | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Pyridoxal 5'-phosphate synthase subunit SNO1; Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase; Belongs to the glutaminase PdxT/SNO family. | 0.470 |
FYV7 | ECM12 | YLR068W | YHR021W-A | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.602 |
FYV7 | LCP5 | YLR068W | YER127W | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | 0.713 |
FYV7 | NGL3 | YLR068W | YML118W | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.465 |
HMS1 | ECM12 | YOR032C | YHR021W-A | bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.444 |
LCP5 | ECM12 | YER127W | YHR021W-A | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.596 |
LCP5 | FYV7 | YER127W | YLR068W | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin. | 0.713 |
LCP5 | NGL3 | YER127W | YML118W | U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus. | 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication. | 0.441 |
MCH2 | ECM12 | YKL221W | YHR021W-A | Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.538 |