| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC55 | PPE1 | YGL190C | YHR075C | Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55. | Protein phosphatase methylesterase 1; Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; Belongs to the AB hydrolase superfamily. | 0.923 |
| CDC55 | PPH21 | YGL190C | YDL134C | Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55. | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; Belongs to the PPP phosphatase family. PP-2A subfamily. | 0.999 |
| CDC55 | PPM1 | YGL190C | YDR435C | Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55. | Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth. | 0.934 |
| CDC55 | TPD3 | YGL190C | YAL016W | Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55. | Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III. | 0.999 |
| MRP17 | MRPS17 | YKL003C | YMR188C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRP17 | MRPS8 | YKL003C | YMR158W | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit. | 0.998 |
| MRP17 | PPE1 | YKL003C | YHR075C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Protein phosphatase methylesterase 1; Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; Belongs to the AB hydrolase superfamily. | 0.929 |
| MRP17 | QRI5 | YKL003C | YLR204W | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA. | 0.996 |
| MRP17 | RSM22 | YKL003C | YKL155C | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase. | 0.988 |
| MRP17 | VAR1 | YKL003C | Q0140 | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions. | 0.980 |
| MRPS17 | MRP17 | YMR188C | YKL003C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | 0.999 |
| MRPS17 | MRPS8 | YMR188C | YMR158W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRPS17 | PPE1 | YMR188C | YHR075C | Mitochondrial ribosomal protein of the small subunit. | Protein phosphatase methylesterase 1; Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; Belongs to the AB hydrolase superfamily. | 0.915 |
| MRPS17 | QRI5 | YMR188C | YLR204W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA. | 0.996 |
| MRPS17 | RSM22 | YMR188C | YKL155C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase. | 0.997 |
| MRPS17 | VAR1 | YMR188C | Q0140 | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions. | 0.984 |
| MRPS8 | MRP17 | YMR158W | YKL003C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator. | 0.998 |
| MRPS8 | MRPS17 | YMR158W | YMR188C | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial ribosomal protein of the small subunit. | 0.999 |
| MRPS8 | PPE1 | YMR158W | YHR075C | Mitochondrial ribosomal protein of the small subunit. | Protein phosphatase methylesterase 1; Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; Belongs to the AB hydrolase superfamily. | 0.928 |
| MRPS8 | QRI5 | YMR158W | YLR204W | Mitochondrial ribosomal protein of the small subunit. | Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA. | 0.993 |
