node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECM16 | KRR1 | YMR128W | YCL059C | Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis. | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family. | 0.999 |
ECM16 | YHR127W | YMR128W | YHR127W | Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis. | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | 0.673 |
ECM16 | YRA1 | YMR128W | YDR381W | Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis. | Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member. | 0.465 |
KRR1 | ECM16 | YCL059C | YMR128W | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family. | Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis. | 0.999 |
KRR1 | YHR127W | YCL059C | YHR127W | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family. | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | 0.633 |
SAC3 | STO1 | YDR159W | YMR125W | Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP). | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | 0.702 |
SAC3 | YHR127W | YDR159W | YHR127W | Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP). | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | 0.615 |
SAC3 | YRA1 | YDR159W | YDR381W | Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP). | Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member. | 0.918 |
SHE1 | YHR127W | YBL031W | YHR127W | Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function. | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | 0.805 |
SHE1 | YHR131C | YBL031W | YHR131C | Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function. | PH domain-containing protein YHR131C; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication. | 0.799 |
STO1 | SAC3 | YMR125W | YDR159W | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP). | 0.702 |
STO1 | YHR127W | YMR125W | YHR127W | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | 0.618 |
STO1 | YRA1 | YMR125W | YDR381W | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member. | 0.982 |
YDR018C | YHR127W | YDR018C | YHR127W | Uncharacterized acyltransferase YDR018C; Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication. | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | 0.754 |
YDR018C | YHR202W | YDR018C | YHR202W | Uncharacterized acyltransferase YDR018C; Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication. | Uncharacterized protein YHR202W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization. | 0.851 |
YHR127W | ECM16 | YHR127W | YMR128W | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis. | 0.673 |
YHR127W | KRR1 | YHR127W | YCL059C | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family. | 0.633 |
YHR127W | SAC3 | YHR127W | YDR159W | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP). | 0.615 |
YHR127W | SHE1 | YHR127W | YBL031W | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function. | 0.805 |
YHR127W | STO1 | YHR127W | YMR125W | Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis. | Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family. | 0.618 |