node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARP1 | ARP10 | YHR129C | YDR106W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | 0.996 |
ARP1 | ARP2 | YHR129C | YDL029W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.923 |
ARP1 | ARP4 | YHR129C | YJL081C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.936 |
ARP1 | DYN1 | YHR129C | YKR054C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p. | 0.960 |
ARP1 | JNM1 | YHR129C | YMR294W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Nuclear migration protein JNM1; Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B. | 0.999 |
ARP1 | KAR9 | YHR129C | YPL269W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Karyogamy protein KAR9; Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli. | 0.935 |
ARP1 | LDB18 | YHR129C | YLL049W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Protein LDB18; Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24. | 0.975 |
ARP1 | MYO1 | YHR129C | YHR023W | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Myosin-1; Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively. | 0.945 |
ARP1 | NIP100 | YHR129C | YPL174C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Protein NIP100; Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued). | 0.998 |
ARP1 | SAC6 | YHR129C | YDR129C | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant. | 0.943 |
ARP10 | ARP1 | YDR106W | YHR129C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | 0.996 |
ARP10 | ARP2 | YDR106W | YDL029W | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.867 |
ARP10 | ARP4 | YDR106W | YJL081C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.952 |
ARP10 | DYN1 | YDR106W | YKR054C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p. | 0.663 |
ARP10 | JNM1 | YDR106W | YMR294W | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Nuclear migration protein JNM1; Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B. | 0.998 |
ARP10 | LDB18 | YDR106W | YLL049W | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Protein LDB18; Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24. | 0.956 |
ARP10 | NIP100 | YDR106W | YPL174C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Protein NIP100; Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued). | 0.970 |
ARP10 | SAC6 | YDR106W | YDR129C | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant. | 0.668 |
ARP2 | ARP1 | YDL029W | YHR129C | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin. | 0.923 |
ARP2 | ARP10 | YDL029W | YDR106W | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily. | 0.867 |