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SPO16 protein (Saccharomyces cerevisiae) - STRING interaction network
"SPO16" - Meiosis-specific protein involved in synaptonemal complex assembly in Saccharomyces cerevisiae
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Known Interactions
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Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SPO16Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation; Necessary for efficient spore formation (198 aa)    
Predicted Functional Partners:
SPO22
Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis; Involved in chromosome segregation during sporulation (975 aa)
       
 
  0.802
MSH5
Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans; Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (901 aa)
           
  0.793
MAE1
Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids (669 aa)
       
      0.743
MSH4
Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein; Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (878 aa)
           
  0.742
SPO11
Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The action of SPO11 is important in setting off a regulatory chain of events encompassing 5’ to 3’ resection. When there are no SPO11-DSBs, resection of a site specific VDE-DSB takes place but it is faster than in wild- [...] (398 aa)
           
  0.679
HFM1
Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity; DNA-dependent ATPase. Required in the control of double strand breaks transition and crossover during meiosis. Unwinds DNA in the 3’ TO 5’ direction. Prefers single-stranded DNA (1187 aa)
           
  0.627
GMC2
Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor; Probable transcriptional activator involved in meiotic prophase and synaptonemal complex (SC) assembly (188 aa)
           
  0.575
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure; May be involved in cell wall organization and biogenesis (302 aa)
           
  0.573
YMR114C
Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene (368 aa)
           
  0.520
ZIP2
Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis. Required for the normal localization of MSH4 to chromosomes (704 aa)
           
  0.511
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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