Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AIM18Altered inheritance of mitochondria protein 18, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss. (321 aa)    
Predicted Functional Partners:
PUF3
mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins.
    
 
 0.932
YKL111C
Putative uncharacterized protein YKL111C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1.
      
 0.810
MRX11
MIOREX complex component 11; Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length.
   
 
 0.760
YFR032C-B
Uncharacterized protein YFR032C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.
    
 
 0.748
YBR292C
Uncharacterized protein YBR292C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene.
      
 0.747
YDR286C
Glutaredoxin-like protein YDR286C; Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; Belongs to the glutaredoxin family. YDR286C subfamily.
   
  
 0.694
YGR161W-C
Uncharacterized protein YGR161W-C; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species.
   
  
 0.693
MRX8
MIOREX complex component 8; Protein that associates with mitochondrial ribosome; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene.
   
  
 0.677
FMP10
Uncharacterized mitochondrial membrane protein FMP10; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the FMP10 family.
   
 
 0.675
AIM34
Altered inheritance of mitochondria protein 34, mitochondrial; Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss.
   
  
 0.664
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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