node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRG1 | GPA2 | YHR209W | YER020W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus | 0.656 |
CRG1 | KDX1 | YHR209W | YKL161C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | 0.736 |
CRG1 | NAR1 | YHR209W | YNL240C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Cytosolic Fe-S cluster assembly factor NAR1; Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf | 0.736 |
CRG1 | NCW2 | YHR209W | YLR194C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | 0.721 |
CRG1 | PIR3 | YHR209W | YKL163W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication | 0.659 |
CRG1 | PRM5 | YHR209W | YIL117C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | 0.737 |
CRG1 | SLT2 | YHR209W | YHR030C | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Mitogen-activated protein kinase SLT2/MPK1; Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway | 0.708 |
CRG1 | SRL3 | YHR209W | YKR091W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication | 0.930 |
CRG1 | YNL092W | YHR209W | YNL092W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Carnosine N-methyltransferase; S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene; Belongs to the carnosine N-methyltransferase family | 0.696 |
CRG1 | YPL088W | YHR209W | YPL088W | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | Putative aryl-alcohol dehydrogenase aad16; Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance | 0.655 |
GPA2 | CRG1 | YER020W | YHR209W | Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | 0.656 |
GPA2 | KDX1 | YER020W | YKL161C | Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | 0.487 |
GPA2 | SLT2 | YER020W | YHR030C | Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus | Mitogen-activated protein kinase SLT2/MPK1; Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway | 0.948 |
KDX1 | CRG1 | YKL161C | YHR209W | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily | 0.736 |
KDX1 | GPA2 | YKL161C | YER020W | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus | 0.487 |
KDX1 | NCW2 | YKL161C | YLR194C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition | 0.681 |
KDX1 | PIR3 | YKL161C | YKL163W | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication | 0.542 |
KDX1 | PRM5 | YKL161C | YIL117C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication | 0.733 |
KDX1 | SLT2 | YKL161C | YHR030C | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Mitogen-activated protein kinase SLT2/MPK1; Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway | 0.603 |
KDX1 | SRL3 | YKL161C | YKR091W | Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication | Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication | 0.657 |