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IRC24 protein (Saccharomyces cerevisiae) - STRING interaction network
"IRC24" - Putative benzil reductase in Saccharomyces cerevisiae
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second shell of interactors
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proteins of unknown 3D structure
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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IRC24Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci; Reduces benzil stereospecifically to (S)-benzoin. Is probably involved in a pathway contributing to genomic integrity (263 aa)    
Predicted Functional Partners:
YIR035C
Putative cytoplasmic protein of unknown function (254 aa)
   
 
 
0.908
TPK1
cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p (397 aa)
     
 
    0.906
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; Thiol-specific antioxidant protein with alkyl hydroperoxidase activity. Involved in osmotic stress resistance and detoxification of the cell. Preferentially eliminates organic peroxides rather than H(2)O(2). Involved in cellular Mn(2+) homeostasis (176 aa)
       
      0.732
SDO1
Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2- like GTPase RIA1, may trigger the GTP-dependent release of TIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating TIF6 recycling to the nucleus, where it is requ [...] (250 aa)
       
      0.732
YDL114W
Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene (308 aa)
   
     
  0.688
GTT1
ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p (234 aa)
     
        0.650
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5’- untranslated leaders of mitochondrial mRNAs (360 aa)
     
      0.641
YDL071C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W (124 aa)
           
  0.636
IRC6
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; Involved in gross chromosomal rearrangements (GCRs) and telomere healing (237 aa)
           
  0.621
SCO1
Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins; Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX (295 aa)
     
      0.609
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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