node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA135 | RPC10 | YPR010C | YHR143W-A | RNA polymerase I second largest subunit A135. | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | 0.999 |
RPA135 | RRN11 | YPR010C | YML043C | RNA polymerase I second largest subunit A135. | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p. | 0.938 |
RPA135 | RRN3 | YPR010C | YKL125W | RNA polymerase I second largest subunit A135. | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family. | 0.999 |
RPA135 | RRN6 | YPR010C | YBL014C | RNA polymerase I second largest subunit A135. | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p. | 0.885 |
RPA135 | RRN7 | YPR010C | YJL025W | RNA polymerase I second largest subunit A135. | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family. | 0.985 |
RPA135 | RRN9 | YPR010C | YMR270C | RNA polymerase I second largest subunit A135. | RNA polymerase I-specific transcription initiation factor RRN9; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | 0.556 |
RPA135 | SPT15 | YPR010C | YER148W | RNA polymerase I second largest subunit A135. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.814 |
RPC10 | RPA135 | YHR143W-A | YPR010C | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | RNA polymerase I second largest subunit A135. | 0.999 |
RPC10 | RRN11 | YHR143W-A | YML043C | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p. | 0.893 |
RPC10 | RRN3 | YHR143W-A | YKL125W | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family. | 0.982 |
RPC10 | RRN6 | YHR143W-A | YBL014C | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p. | 0.879 |
RPC10 | RRN7 | YHR143W-A | YJL025W | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family. | 0.984 |
RPC10 | SPT15 | YHR143W-A | YER148W | RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.985 |
RRN10 | RRN11 | YBL025W | YML043C | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p. | 0.983 |
RRN10 | RRN3 | YBL025W | YKL125W | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family. | 0.801 |
RRN10 | RRN5 | YBL025W | YLR141W | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p. | 0.999 |
RRN10 | RRN6 | YBL025W | YBL014C | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p. | 0.987 |
RRN10 | RRN7 | YBL025W | YJL025W | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family. | 0.987 |
RRN10 | RRN9 | YBL025W | YMR270C | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | RNA polymerase I-specific transcription initiation factor RRN9; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | 0.999 |
RRN10 | SPT15 | YBL025W | YER148W | Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I. | TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP. | 0.982 |