node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BFR2 | ESF1 | YDR299W | YDR365C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | 0.978 |
BFR2 | ESF2 | YDR299W | YNR054C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | Pre-rRNA-processing protein ESF2; Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome. | 0.926 |
BFR2 | HAS1 | YDR299W | YMR290C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles. | 0.990 |
BFR2 | HCA4 | YDR299W | YJL033W | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily. | 0.997 |
BFR2 | RRP36 | YDR299W | YOR287C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | rRNA biogenesis protein RRP36; Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; Belongs to the RRP36 family. | 0.953 |
BFR2 | SAS10 | YDR299W | YDL153C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | Something about silencing protein 10; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene. | 0.999 |
BFR2 | SGD1 | YDR299W | YLR336C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | Suppressor of glycerol defect protein 1; Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia. | 0.724 |
BFR2 | UTP14 | YDR299W | YML093W | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | U3 small nucleolar RNA-associated protein 14; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP14 family. | 0.999 |
BFR2 | UTP18 | YDR299W | YJL069C | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats. | 0.999 |
BFR2 | UTP22 | YDR299W | YGR090W | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | U3 small nucleolar RNA-associated protein 22; Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals. | 0.999 |
ESF1 | BFR2 | YDR365C | YDR299W | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock. | 0.978 |
ESF1 | ESF2 | YDR365C | YNR054C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | Pre-rRNA-processing protein ESF2; Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome. | 0.999 |
ESF1 | HAS1 | YDR365C | YMR290C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles. | 0.997 |
ESF1 | HCA4 | YDR365C | YJL033W | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily. | 0.999 |
ESF1 | RRP36 | YDR365C | YOR287C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | rRNA biogenesis protein RRP36; Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; Belongs to the RRP36 family. | 0.562 |
ESF1 | SAS10 | YDR365C | YDL153C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | Something about silencing protein 10; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene. | 0.999 |
ESF1 | SGD1 | YDR365C | YLR336C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | Suppressor of glycerol defect protein 1; Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia. | 0.996 |
ESF1 | UTP14 | YDR365C | YML093W | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | U3 small nucleolar RNA-associated protein 14; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP14 family. | 0.970 |
ESF1 | UTP18 | YDR365C | YJL069C | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats. | 0.999 |
ESF1 | UTP22 | YDR365C | YGR090W | Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels. | U3 small nucleolar RNA-associated protein 22; Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals. | 0.999 |