node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | ARP4 | YFL039C | YJL081C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | 0.999 |
ACT1 | ARP8 | YFL039C | YOR141C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-like protein ARP8; Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity. | 0.999 |
ACT1 | EAF1 | YFL039C | YDR359C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; Belongs to the EAF1 family. | 0.998 |
ACT1 | EPL1 | YFL039C | YFL024C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Enhancer of polycomb-like protein 1; Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains. | 0.999 |
ACT1 | INO80 | YFL039C | YGL150C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin-remodeling ATPase INO80; ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription. | 0.999 |
ACT1 | RVB1 | YFL039C | YDR190C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | RuvB-like protein 1; ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly. | 0.999 |
ACT1 | SWC4 | YFL039C | YGR002C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. | 0.999 |
ACT1 | SWR1 | YFL039C | YDR334W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Helicase SWR1; Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.999 |
ACT1 | TRA1 | YFL039C | YHR099W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Transcription-associated protein 1; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation; Belongs to the PI3/PI4-kinase family. TRA1 subfamily. | 0.994 |
ACT1 | YNG2 | YFL039C | YHR090C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Chromatin modification-related protein YNG2; Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5. | 0.995 |
ARP4 | ACT1 | YJL081C | YFL039C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.999 |
ARP4 | ARP8 | YJL081C | YOR141C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Actin-like protein ARP8; Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity. | 0.999 |
ARP4 | EAF1 | YJL081C | YDR359C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; Belongs to the EAF1 family. | 0.999 |
ARP4 | EPL1 | YJL081C | YFL024C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Enhancer of polycomb-like protein 1; Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains. | 0.999 |
ARP4 | INO80 | YJL081C | YGL150C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin-remodeling ATPase INO80; ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription. | 0.999 |
ARP4 | RVB1 | YJL081C | YDR190C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | RuvB-like protein 1; ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly. | 0.999 |
ARP4 | SWC4 | YJL081C | YGR002C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex. | 0.999 |
ARP4 | SWR1 | YJL081C | YDR334W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Helicase SWR1; Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. | 0.999 |
ARP4 | TRA1 | YJL081C | YHR099W | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Transcription-associated protein 1; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation; Belongs to the PI3/PI4-kinase family. TRA1 subfamily. | 0.999 |
ARP4 | YNG2 | YJL081C | YHR090C | Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes. | Chromatin modification-related protein YNG2; Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5. | 0.999 |