node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCH1 | ENA1 | YGR217W | YDR040C | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | 0.550 |
CCH1 | NHA1 | YGR217W | YLR138W | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH. | 0.580 |
CCH1 | PHO89 | YGR217W | YBR296C | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | Phosphate permease PHO89; Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification. | 0.418 |
CCH1 | TOK1 | YGR217W | YJL093C | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin. | 0.679 |
CCH1 | TRK1 | YGR217W | YJL129C | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication; Belongs to the TrkH potassium transport family. | 0.517 |
CCH1 | TRK2 | YGR217W | YKR050W | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication. | 0.481 |
ENA1 | CCH1 | YDR040C | YGR217W | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function. | 0.550 |
ENA1 | KHA1 | YDR040C | YJL094C | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies. | 0.919 |
ENA1 | NHA1 | YDR040C | YLR138W | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH. | 0.989 |
ENA1 | NHX1 | YDR040C | YDR456W | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Endosomal/prevacuolar sodium/hydrogen exchanger; Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.935 |
ENA1 | PHO89 | YDR040C | YBR296C | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Phosphate permease PHO89; Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification. | 0.694 |
ENA1 | TOK1 | YDR040C | YJL093C | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin. | 0.904 |
ENA1 | TRK1 | YDR040C | YJL129C | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication; Belongs to the TrkH potassium transport family. | 0.849 |
ENA1 | TRK2 | YDR040C | YKR050W | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication. | 0.850 |
ENA1 | VNX1 | YDR040C | YNL321W | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | Low affinity vacuolar monovalent cation/H(+) antiporter; Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.633 |
KHA1 | ENA1 | YJL094C | YDR040C | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies. | P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance. | 0.919 |
KHA1 | NHA1 | YJL094C | YLR138W | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies. | Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH. | 0.968 |
KHA1 | NHX1 | YJL094C | YDR456W | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies. | Endosomal/prevacuolar sodium/hydrogen exchanger; Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.972 |
KHA1 | PHO89 | YJL094C | YBR296C | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies. | Phosphate permease PHO89; Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification. | 0.585 |
KHA1 | TOK1 | YJL094C | YJL093C | K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies. | Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin. | 0.847 |