Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APC11 | VPS55 | YDL008W | YJR044C | Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity. | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | 0.481 |
| MVP1 | PEP1 | YMR004W | YBL017C | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress. | Vacuolar protein sorting/targeting protein VPS10; Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; Belongs to the VPS10-related sortilin family. | 0.636 |
| MVP1 | VPS55 | YMR004W | YJR044C | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress. | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | 0.536 |
| MVP1 | VPS68 | YMR004W | YOL129W | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress. | Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria; Belongs to the UPF0220 family. | 0.519 |
| MVP1 | YKR078W | YMR004W | YKR078W | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YKR078W; Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); YKR078W has a paralog, VPS5, that arose from the whole genome duplication. | 0.806 |
| PEP1 | MVP1 | YBL017C | YMR004W | Vacuolar protein sorting/targeting protein VPS10; Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; Belongs to the VPS10-related sortilin family. | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress. | 0.636 |
| PEP1 | VPS55 | YBL017C | YJR044C | Vacuolar protein sorting/targeting protein VPS10; Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; Belongs to the VPS10-related sortilin family. | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | 0.587 |
| TDA5 | VPS55 | YLR426W | YJR044C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | 0.515 |
| TDA5 | YCR101C | YLR426W | YCR101C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein YCR101C; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene. | 0.510 |
| TDA5 | YDL109C | YLR426W | YDL109C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication. | 0.510 |
| TDA5 | YDR132C | YLR426W | YDR132C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Uncharacterized protein YDR132C; Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication. | 0.517 |
| TDA5 | YGL242C | YLR426W | YGL242C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.589 |
| VPS55 | APC11 | YJR044C | YDL008W | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity. | 0.481 |
| VPS55 | MVP1 | YJR044C | YMR004W | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress. | 0.536 |
| VPS55 | PEP1 | YJR044C | YBL017C | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Vacuolar protein sorting/targeting protein VPS10; Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; Belongs to the VPS10-related sortilin family. | 0.587 |
| VPS55 | TDA5 | YJR044C | YLR426W | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.515 |
| VPS55 | VPS68 | YJR044C | YOL129W | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria; Belongs to the UPF0220 family. | 0.999 |
| VPS55 | YCR101C | YJR044C | YCR101C | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Uncharacterized protein YCR101C; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene. | 0.533 |
| VPS55 | YDL109C | YJR044C | YDL109C | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication. | 0.510 |
| VPS55 | YDR132C | YJR044C | YDR132C | Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family. | Uncharacterized protein YDR132C; Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication. | 0.518 |
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