node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACT1 | ARC15 | YFL039C | YIL062C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | 0.944 |
ACT1 | ARC18 | YFL039C | YLR370C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches. | 0.976 |
ACT1 | ARC19 | YFL039C | YKL013C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4. | 0.957 |
ACT1 | ARC35 | YFL039C | YNR035C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin. | 0.960 |
ACT1 | ARC40 | YFL039C | YBR234C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; Belongs to the WD repeat ARPC1 family. | 0.983 |
ACT1 | ARP2 | YFL039C | YDL029W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.992 |
ACT1 | ARP3 | YFL039C | YJR065C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Actin-related protein 3; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity. | 0.994 |
ACT1 | COF1 | YFL039C | YLL050C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes; Belongs to the actin-binding proteins ADF family. | 0.999 |
ACT1 | LAS17 | YFL039C | YOR181W | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches. | 0.997 |
ACT1 | PFY1 | YFL039C | YOR122C | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS. | 0.999 |
ARC15 | ACT1 | YIL062C | YFL039C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions. | 0.944 |
ARC15 | ARC18 | YIL062C | YLR370C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches. | 0.999 |
ARC15 | ARC19 | YIL062C | YKL013C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4. | 0.999 |
ARC15 | ARC35 | YIL062C | YNR035C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin. | 0.999 |
ARC15 | ARC40 | YIL062C | YBR234C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; Belongs to the WD repeat ARPC1 family. | 0.999 |
ARC15 | ARP2 | YIL062C | YDL029W | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants. | 0.999 |
ARC15 | ARP3 | YIL062C | YJR065C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Actin-related protein 3; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity. | 0.999 |
ARC15 | COF1 | YIL062C | YLL050C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes; Belongs to the actin-binding proteins ADF family. | 0.481 |
ARC15 | LAS17 | YIL062C | YOR181W | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches. | 0.987 |
ARC15 | PFY1 | YIL062C | YOR122C | Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family. | Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS. | 0.507 |