node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBP1 | MDM1 | YJL209W | YML104C | Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress. | Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease. | 0.530 |
CBP1 | YBL108W | YJL209W | YBL108W | Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress. | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | 0.599 |
CBP1 | YJR079W | YJL209W | YJR079W | Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress. | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. | 0.601 |
HAC1 | YJR079W | YFL031W | YJR079W | Transcriptional activator HAC1; Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; two functional forms of Hac1p are produced; translation initiation is repressed under non-stress conditions; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. | 0.418 |
MDM1 | CBP1 | YML104C | YJL209W | Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease. | Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress. | 0.530 |
MDM1 | YBL108W | YML104C | YBL108W | Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease. | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | 0.406 |
MDM1 | YJR079W | YML104C | YJR079W | Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease. | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. | 0.416 |
YAR066W | YBL108W | YAR066W | YBL108W | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | 0.902 |
YAR066W | YDR543C | YAR066W | YDR543C | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. | Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.799 |
YAR066W | YHL050C | YAR066W | YHL050C | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. | Uncharacterized protein YHL050C; Putative protein of unknown function; potential Cdc28p substrate. | 0.702 |
YAR066W | YJR079W | YAR066W | YJR079W | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. | 0.601 |
YBL108W | CBP1 | YBL108W | YJL209W | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress. | 0.599 |
YBL108W | MDM1 | YBL108W | YML104C | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease. | 0.406 |
YBL108W | YAR066W | YBL108W | YAR066W | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. | 0.902 |
YBL108W | YDR543C | YBL108W | YDR543C | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.916 |
YBL108W | YHL050C | YBL108W | YHL050C | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | Uncharacterized protein YHL050C; Putative protein of unknown function; potential Cdc28p substrate. | 0.475 |
YBL108W | YJR079W | YBL108W | YJR079W | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. | 0.835 |
YDR543C | YAR066W | YDR543C | YAR066W | Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication. | 0.799 |
YDR543C | YBL108W | YDR543C | YBL108W | Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family. | 0.916 |
YDR543C | YJR079W | YDR543C | YJR079W | Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration. | 0.702 |