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EMC2 protein (Saccharomyces cerevisiae) - STRING interaction network
"EMC2" - Member of a transmembrane complex required for efficient folding of proteins in the ER in Saccharomyces cerevisiae
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Predicted Interactions
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EMC2Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (292 aa)    
Predicted Functional Partners:
EMC3
Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (253 aa)
     
  0.999
EMC1
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (760 aa)
     
  0.999
EMC4
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (190 aa)
     
  0.999
EMC6
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (108 aa)
       
  0.998
EMC5
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (141 aa)
       
  0.980
UBX4
UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfo /.../roteins to the proteasome; Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway (416 aa)
     
      0.868
CUZ1
Putative protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of hu /.../RAP, which stimulates proteasome activity in response to arsenic; May have a role in the ubiquitin-proteasome system (UPS) protecting cells from metalloid-induced proteotoxicity (274 aa)
     
      0.749
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations; Involved in inorganic phosphate transport. Also involved in telomere length regulation and maintenance (188 aa)
     
      0.719
DER1
Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p; Component of the endoplasmic reticulum-associated degradation (ERAD) pathway. Specifically required for the ERAD-L pathway which mediates the degradation of proteins with misfolded lumenal domains within the endoplasmic reticulum (211 aa)
       
 
  0.634
EMC10
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein (205 aa)
           
  0.578
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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