| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRP1 | ECM27 | YGL007W | YJR106W | Uncharacterized protein BRP1; Putative protein of unknown function; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1. | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | 0.533 |
| ECM12 | ECM27 | YHR021W-A | YJR106W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | 0.648 |
| ECM12 | ECM30 | YHR021W-A | YLR436C | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm. | 0.638 |
| ECM12 | ECM8 | YHR021W-A | YBR076W | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | Non-essential protein of unknown function. | 0.552 |
| ECM27 | BRP1 | YJR106W | YGL007W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Uncharacterized protein BRP1; Putative protein of unknown function; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1. | 0.533 |
| ECM27 | ECM12 | YJR106W | YHR021W-A | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.648 |
| ECM27 | ECM30 | YJR106W | YLR436C | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm. | 0.548 |
| ECM27 | ECM8 | YJR106W | YBR076W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Non-essential protein of unknown function. | 0.496 |
| ECM27 | GDT1 | YJR106W | YBR187W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | GCR1-dependent translation factor 1; Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant; Belongs to the GDT1 family. | 0.490 |
| ECM27 | HEK2 | YJR106W | YBL032W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | 0.457 |
| ECM27 | MTF1 | YJR106W | YMR228W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. | 0.634 |
| ECM27 | NHX1 | YJR106W | YDR456W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Endosomal/prevacuolar sodium/hydrogen exchanger; Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.721 |
| ECM27 | VNX1 | YJR106W | YNL321W | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Low affinity vacuolar monovalent cation/H(+) antiporter; Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. | 0.492 |
| ECM27 | YBR196C-A | YJR106W | YBR196C-A | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | Uncharacterized protein YBR196C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR. | 0.580 |
| ECM30 | ECM12 | YLR436C | YHR021W-A | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.638 |
| ECM30 | ECM27 | YLR436C | YJR106W | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm. | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | 0.548 |
| ECM30 | ECM8 | YLR436C | YBR076W | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm. | Non-essential protein of unknown function. | 0.464 |
| ECM30 | HEK2 | YLR436C | YBL032W | Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm. | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | 0.475 |
| ECM8 | ECM12 | YBR076W | YHR021W-A | Non-essential protein of unknown function. | Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity. | 0.552 |
| ECM8 | ECM27 | YBR076W | YJR106W | Non-essential protein of unknown function. | Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p. | 0.496 |
