node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CFT2 | IPA1 | YLR115W | YJR141W | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | Uncharacterized protein YJR141W; Essential protein of unknown function. | 0.695 |
CFT2 | MPE1 | YLR115W | YKL059C | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | Protein MPE1; Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; both the zinc knuckle and RING finger are required for pre-mRNA binding; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia. | 0.999 |
CFT2 | PTA1 | YLR115W | YAL043C | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | Pre-tRNA-processing protein PTA1; Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII. | 0.999 |
CFT2 | PTI1 | YLR115W | YGR156W | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | Protein PTI1; Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64. | 0.999 |
CFT2 | YSH1 | YLR115W | YLR277C | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. | 0.999 |
CFT2 | YTH1 | YLR115W | YPR107C | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | mRNA 3'-end-processing protein YTH1; Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia. | 0.999 |
FMP27 | FSF1 | YLR454W | YOR271C | Protein FMP27, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Sideroflexin FSF1; Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis. | 0.606 |
FMP27 | IPA1 | YLR454W | YJR141W | Protein FMP27, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Uncharacterized protein YJR141W; Essential protein of unknown function. | 0.538 |
FSF1 | FMP27 | YOR271C | YLR454W | Sideroflexin FSF1; Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis. | Protein FMP27, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.606 |
FSF1 | IPA1 | YOR271C | YJR141W | Sideroflexin FSF1; Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis. | Uncharacterized protein YJR141W; Essential protein of unknown function. | 0.698 |
IPA1 | CFT2 | YJR141W | YLR115W | Uncharacterized protein YJR141W; Essential protein of unknown function. | Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. | 0.695 |
IPA1 | FMP27 | YJR141W | YLR454W | Uncharacterized protein YJR141W; Essential protein of unknown function. | Protein FMP27, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.538 |
IPA1 | FSF1 | YJR141W | YOR271C | Uncharacterized protein YJR141W; Essential protein of unknown function. | Sideroflexin FSF1; Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis. | 0.698 |
IPA1 | MPE1 | YJR141W | YKL059C | Uncharacterized protein YJR141W; Essential protein of unknown function. | Protein MPE1; Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; both the zinc knuckle and RING finger are required for pre-mRNA binding; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia. | 0.999 |
IPA1 | PAM1 | YJR141W | YDR251W | Uncharacterized protein YJR141W; Essential protein of unknown function. | Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication. | 0.510 |
IPA1 | PTA1 | YJR141W | YAL043C | Uncharacterized protein YJR141W; Essential protein of unknown function. | Pre-tRNA-processing protein PTA1; Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII. | 0.596 |
IPA1 | PTI1 | YJR141W | YGR156W | Uncharacterized protein YJR141W; Essential protein of unknown function. | Protein PTI1; Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64. | 0.469 |
IPA1 | UBC11 | YJR141W | YOR339C | Uncharacterized protein YJR141W; Essential protein of unknown function. | Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2. | 0.616 |
IPA1 | YSH1 | YJR141W | YLR277C | Uncharacterized protein YJR141W; Essential protein of unknown function. | Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. | 0.865 |
IPA1 | YTH1 | YJR141W | YPR107C | Uncharacterized protein YJR141W; Essential protein of unknown function. | mRNA 3'-end-processing protein YTH1; Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia. | 0.476 |