| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DSF1 | HXT16 | YEL070W | YJR158W | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.421 |
| DSF1 | MAN2 | YEL070W | YNR073C | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication. | 0.496 |
| DSF1 | SOR1 | YEL070W | YJR159W | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.935 |
| DSF1 | SOR2 | YEL070W | YDL246C | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase. | 0.927 |
| FLO10 | HXT16 | YKR102W | YJR158W | Flocculation protein FLO10; Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth. | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.425 |
| HEK2 | HXT16 | YBL032W | YJR158W | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.457 |
| HEK2 | MAL32 | YBL032W | YBR299W | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family. | 0.457 |
| HEK2 | SOR1 | YBL032W | YJR159W | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.457 |
| HXT16 | DSF1 | YJR158W | YEL070W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | 0.421 |
| HXT16 | FLO10 | YJR158W | YKR102W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Flocculation protein FLO10; Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth. | 0.425 |
| HXT16 | HEK2 | YJR158W | YBL032W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | 0.457 |
| HXT16 | MAL32 | YJR158W | YBR299W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family. | 0.423 |
| HXT16 | MAN2 | YJR158W | YNR073C | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication. | 0.538 |
| HXT16 | SNF1 | YJR158W | YDR477W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase. | 0.908 |
| HXT16 | SNO3 | YJR158W | YFL060C | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Probable pyridoxal 5'-phosphate synthase subunit SNO3; Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin. | 0.482 |
| HXT16 | SOR1 | YJR158W | YJR159W | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.453 |
| HXT16 | SOR2 | YJR158W | YDL246C | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase. | 0.413 |
| MAL32 | HEK2 | YBR299W | YBL032W | Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family. | Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K. | 0.457 |
| MAL32 | HXT16 | YBR299W | YJR158W | Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family. | Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.423 |
| MAN2 | DSF1 | YNR073C | YEL070W | Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication. | Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication. | 0.496 |
