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MET14 protein (Saccharomyces cerevisiae) - STRING interaction network
"MET14" - Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism in Saccharomyces cerevisiae
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MET14Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism; Catalyzes the synthesis of activated sulfate (202 aa)    
Predicted Functional Partners:
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5’-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids (511 aa)
 
 
  0.999
MET16
3’-phosphoadenylsulfate reductase, reduces 3’-phosphoadenylyl sulfate to adenosine-3’,5’-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier (261 aa)
 
  0.999
MET5
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine; Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate (1442 aa)
   
 
  0.998
MET10
Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide; This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate (1035 aa)
   
  0.998
MET1
S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Siroheme synthase involved in methionine biosynthesis (593 aa)
   
   
  0.976
MET2
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway (486 aa)
     
   
  0.975
TEF1
Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; GTP-binding component of the eukaryotic elongation factor 1 complex (eEF1). In its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. [...] (458 aa)
 
 
  0.955
TEF2
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus (458 aa)
 
 
  0.955
FAD1
Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (306 aa)
   
  0.947
MET22
Bisphosphate-3’-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3’-phosphoadenosine-5’-phosphate and 3’-phosphoadenosine-5’-phosphosulfate, intermediates of the sulfate assimilation pathway; Converts adenosine 3’-phosphate 5’-phosphosulfate (PAPS) to adenosine 5’-phosphosulfate (APS) and 3’(2’)-phosphoadenosine 5’- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. Involved in salt tolerance. Confers resistance to lithium (357 aa)
   
 
  0.946
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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