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HCS1 protein (Saccharomyces cerevisiae) - STRING interaction network
"HCS1" - Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis in Saccharomyces cerevisiae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HCS1Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities; DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication (683 aa)    
Predicted Functional Partners:
TAF14
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; Functions as a component of the DNA-binding general transcription factor complex TFIID, the RNA polymerase II associated general transcription factor complex TFIIF, and the chromatin-remodeling complex SWI/SNF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II thro [...] (244 aa)
         
  0.910
INO80
ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3’ to 5’ DNA helicase activity in vitro; has a role in modulating stress gene transcription; Putative DNA helicase component of the INO80 complex which remodels chromatin by shifting nucleosomes. Its ability to induce transcription of some phosphate-responsive genes is modulated by inositol polyphosphates. The INO80 complex is involved in DNA repair by associating to ’Ser-129’ phosphorylated H2A histones as a response to DNA damage (1489 aa)
     
    0.907
NHP10
Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex (203 aa)
       
    0.901
IES4
Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses (116 aa)
         
    0.900
ARP5
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex (755 aa)
         
    0.900
IES3
Subunit of the INO80 chromatin remodeling complex; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex (250 aa)
         
    0.900
IES1
Subunit of the INO80 chromatin remodeling complex; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex (692 aa)
         
    0.900
RVB2
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes. Its ability [...] (471 aa)
       
  0.774
RVB1
Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes. Its ability [...] (463 aa)
       
  0.774
ACT1
Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
         
  0.728
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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