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YKL075C protein (Saccharomyces cerevisiae) - STRING interaction network
"YKL075C" - Putative protein of unknown function in Saccharomyces cerevisiae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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YKL075CPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin (450 aa)    
Predicted Functional Partners:
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1; With MSL1, acts as a negative regulator of salt tolerance (1240 aa)
       
      0.731
DOT6
Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. DOT [...] (670 aa)
       
      0.699
IBD2
Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p; Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex (351 aa)
       
      0.691
XRS2
Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling; During meiosis is involved in homologous recombination and during vegetative growth it is necessary for DNA repair. It probably regulates the 5’-3’ exonuclease degradation of double strand breaks either at the initiation stage or a later stage (854 aa)
       
 
  0.582
HRQ1
Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS); Helicase with 3’-5’ helicase activity involved in genome stability (PubMed-23456718, PubMed-24440721, PubMed-24700328). Functions in the RAD4-dependent nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair (PubMed-24440721, PubMed-24682993). Unwinds relatively long duplex DNA up to 120-bp and requires a long 3’-tail of at least 70 nu [...] (1077 aa)
           
  0.573
ADF1
Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand; Transcriptional repressor which negatively regulates transcription of FYV5 by binding to the promoter on the sense strand (113 aa)
           
  0.518
IRC21
Protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study; Involved in resistance to carboplatin and cisplatin. Is probably involved in a pathway contributing to genomic integrity (201 aa)
           
  0.487
YDR433W
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (146 aa)
           
  0.483
TSR2
Protein with a potential role in pre-rRNA processing; Required for 20S pre-rRNA processing (205 aa)
           
  0.482
IMO32
Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 (342 aa)
           
  0.442
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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