node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DBP8 | DHR2 | YHR169W | YKL078W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | 0.999 |
DBP8 | ENP1 | YHR169W | YBR247C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family. | 0.999 |
DBP8 | FAL1 | YHR169W | YDR021W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | ATP-dependent RNA helicase FAL1; Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3; Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. | 0.656 |
DBP8 | KRR1 | YHR169W | YCL059C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family. | 0.944 |
DBP8 | NOP14 | YHR169W | YDL148C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; Belongs to the NOP14 family. | 0.926 |
DBP8 | PRP43 | YHR169W | YGL120C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43; RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. | 0.995 |
DBP8 | SAS10 | YHR169W | YDL153C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | Something about silencing protein 10; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene. | 0.999 |
DBP8 | UTP18 | YHR169W | YJL069C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats. | 0.954 |
DBP8 | UTP25 | YHR169W | YIL091C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | U3 small nucleolar RNA-associated protein 25; Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis. | 0.982 |
DBP8 | UTP5 | YHR169W | YDR398W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | U3 small nucleolar RNA-associated protein 5; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit. | 0.841 |
DHR2 | DBP8 | YKL078W | YHR169W | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. | 0.999 |
DHR2 | ENP1 | YKL078W | YBR247C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family. | 0.999 |
DHR2 | FAL1 | YKL078W | YDR021W | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | ATP-dependent RNA helicase FAL1; Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3; Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. | 0.999 |
DHR2 | KRR1 | YKL078W | YCL059C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family. | 0.999 |
DHR2 | NOP14 | YKL078W | YDL148C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; Belongs to the NOP14 family. | 0.999 |
DHR2 | PRP43 | YKL078W | YGL120C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43; RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. | 0.999 |
DHR2 | SAS10 | YKL078W | YDL153C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | Something about silencing protein 10; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene. | 0.999 |
DHR2 | UTP18 | YKL078W | YJL069C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats. | 0.999 |
DHR2 | UTP25 | YKL078W | YIL091C | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | U3 small nucleolar RNA-associated protein 25; Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis. | 0.999 |
DHR2 | UTP5 | YKL078W | YDR398W | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily. | U3 small nucleolar RNA-associated protein 5; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit. | 0.999 |