node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DBP8 | DHR2 | YHR169W | YKL078W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | 0.999 |
DBP8 | ENP1 | YHR169W | YBR247C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family | 0.999 |
DBP8 | FAL1 | YHR169W | YDR021W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | ATP-dependent RNA helicase FAL1; Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3 | 0.948 |
DBP8 | HCA4 | YHR169W | YJL033W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily | 0.989 |
DBP8 | MPP10 | YHR169W | YJR002W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | U3 small nucleolar RNA-associated protein MPP10; Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p | 0.994 |
DBP8 | NOP19 | YHR169W | YGR251W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | Nucleolar protein 19; Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes | 0.923 |
DBP8 | SGD1 | YHR169W | YLR336C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | Suppressor of glycerol defect protein 1; Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia | 0.821 |
DBP8 | SLX9 | YHR169W | YGR081C | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | Ribosome biogenesis protein SLX9; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant | 0.981 |
DBP8 | UTP14 | YHR169W | YML093W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | U3 small nucleolar RNA-associated protein 14; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP14 family | 0.984 |
DBP8 | UTP22 | YHR169W | YGR090W | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | U3 small nucleolar RNA-associated protein 22; Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals | 0.997 |
DHR2 | DBP8 | YKL078W | YHR169W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p | 0.999 |
DHR2 | ENP1 | YKL078W | YBR247C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family | 0.998 |
DHR2 | FAL1 | YKL078W | YDR021W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | ATP-dependent RNA helicase FAL1; Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3 | 0.997 |
DHR2 | HCA4 | YKL078W | YJL033W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily | 0.998 |
DHR2 | MPP10 | YKL078W | YJR002W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | U3 small nucleolar RNA-associated protein MPP10; Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p | 0.999 |
DHR2 | NOP19 | YKL078W | YGR251W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Nucleolar protein 19; Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes | 0.999 |
DHR2 | SGD1 | YKL078W | YLR336C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Suppressor of glycerol defect protein 1; Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia | 0.998 |
DHR2 | SLX9 | YKL078W | YGR081C | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | Ribosome biogenesis protein SLX9; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant | 0.999 |
DHR2 | UTP14 | YKL078W | YML093W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | U3 small nucleolar RNA-associated protein 14; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP14 family | 0.999 |
DHR2 | UTP22 | YKL078W | YGR090W | Probable atp-dependent rna helicase dhr2; Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis | U3 small nucleolar RNA-associated protein 22; Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals | 0.999 |