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PMU1 protein (Saccharomyces cerevisiae) - STRING interaction network
"PMU1" - Putative phosphomutase, contains a region homologous to the active site of phosphomutases in Saccharomyces cerevisiae
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second shell of interactors
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
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PMU1Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; Probable phosphomutase that may have a function related to the manipulation of phosphate groups on carbohydrates. Reduces trehalose-6-phosphate levels when overexpressed in TPS2-deleted cells. Reduces 5’-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR) levels, a metabolic intermediate at the crossroads between AMP and histidine biosynthesis pathways, when [...] (295 aa)    
Predicted Functional Partners:
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth; Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway (426 aa)
     
      0.707
YTA12
Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; Acts as a component of the m-AAA protease complex which is a ATP-dependent metalloprotease mediating degradation of non- assembled mitochondrial inner membrane proteins. The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes. Function both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides (825 aa)
       
      0.699
VHR2
Non-essential nuclear protein; null mutation has global effects on transcription; Transcription factor that regulates ERG9, but seems to have a more global function in transcription (505 aa)
       
      0.679
ADE16
Enzyme of ’de novo’ purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine (591 aa)
       
 
  0.644
YBR013C
Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein (129 aa)
           
  0.639
SNM1
Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP; Essential component of the MRP ribonucleoprotein endoribonuclease that cleaves mitochondrial primer RNA sequences (198 aa)
           
  0.622
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process (896 aa)
       
 
  0.545
RMA1
Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Conversion of folates to polyglutamate derivatives (430 aa)
           
  0.540
ADE17
Enzyme of ’de novo’ purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine (592 aa)
       
 
  0.519
YMR103C
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data (120 aa)
           
  0.513
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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