STRINGSTRING
HYM1 protein (Saccharomyces cerevisiae) - STRING interaction network
"HYM1" - Component of the RAM signaling network in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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HYM1Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response (399 aa)    
Predicted Functional Partners:
KIC1
Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis; Protein kinase involved in morphogenesis and cell integrity (1080 aa)
     
  0.998
SPS1
Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis; Serine/threonine protein kinase required for spore wall development (490 aa)
     
  0.961
TAO3
Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p; Seems to play a role in cell morphogenesis (2376 aa)
       
 
  0.952
CBK1
Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates /.../zation and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation (756 aa)
     
 
  0.941
MOB2
Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; simi /.../ Mob1p; Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. Required for coordinating polarized cell growth during interphase with the onset of mitosis. Required for mother/daughter cell separation after cytokinesis. Also has a role i [...] (287 aa)
       
 
  0.939
SNF1
AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8. Phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, and which is required for transcriptional activation through TBP recruitment to the promoters (633 aa)
       
  0.932
SOG2
Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis; Required for proper cell morphogenesis and cell separation after mitosis. Functions in the RAM (regulation of ACE2 activity and cellular morphogenesis) signaling network and is required for proper ACE2 localization and CBK1 kinase activity (791 aa)
       
 
  0.925
CLA4
Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; Involved in budding and cytokinesis (842 aa)
         
  0.911
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; One of the three SNF1 protein kinases (with SAK1 and ELM1) which are required for growth on nonfermentable carbon sources and nonpreferred sugars and for response to environmental stress. Activates SNF1 by phosphorylation of its activation-loop ’Thr-210’. Required for the regulation by SNF1 of the transcription of a large set of genes, the modificatio [...] (560 aa)
         
  0.904
SAK1
Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; Serine/threonine-protein kinase that phosphorylates SNF1, the catalytic subunit of the SNF1 kinase complex. Acts as an activator of the SNF1 kinase complex and controls its nuclear localization upon glucose and nitrogen depletion. Also required for SNF1 kinase activation under other stress conditions like alkaline pH or presence of cadmium (1142 aa)
         
  0.904
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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