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CBT1 protein (Saccharomyces cerevisiae) - STRING interaction network
"CBT1" - Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts in Saccharomyces cerevisiae
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Known Interactions
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
co-expression
protein homology
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CBT1Protein involved in 5’ end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3’ end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p; Involved in 5’-end processing of mitochondrial COB, 15S rRNA, and RPM1 transcript. May also have a role in 3’-end processing of the COB pre-mRNA (271 aa)    
Predicted Functional Partners:
CTL1
RNA 5’-triphosphatase, localizes to both the nucleus and cytoplasm; Probably involved in an RNA processing event other than mRNA capping. Releases gamma-phosphate from the 5’-end of RNA to produce a diphosphate terminus (320 aa)
       
 
  0.649
CBP1
Mitochondrial protein that interacts with the 5’-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p; Responsible for conferring a stable 5’-end on cytochrome b mRNA (654 aa)
           
  0.638
PET54
Mitochondrial inner membrane protein; binds to the 5’ UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3 (293 aa)
           
  0.519
CBS1
Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5’-untranslated leader; mRNA-specific translational activator of cytochrome b. The cytochrome b (COB) leader RNA may represent the target sequence for CBS1 and CBS2, tethering the COB mRNA to the inner mitochondrial membrane, where cotranslational insertion of cytochrome b into the membrane can occur (229 aa)
           
  0.517
SCD6
Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; Suppressor of clathrin deficiency (349 aa)
       
      0.507
MSF1
Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation (469 aa)
       
      0.507
NGL2
Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3’-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p; Involved in pre-rRNA processing. Required for the final stage of 3’-end maturation of 5.8S rRNA at site E (515 aa)
       
      0.507
YGL159W
Putative protein of unknown function; deletion mutant has no detectable phenotype (370 aa)
           
  0.489
PET127
Protein with a role in 5’-end processing of mitochondrial RNAs, located in the mitochondrial membrane; Could be a component of the mitochondrial translation system with a role in promoting accuracy of translational initiation (800 aa)
           
  0.485
MTF2
Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription; Required for the processing and/or for the stability of the CYTB and COX1 intron-containing pre-mRNAs and of the ATP6 transcript. Could be a stem-loop RNA-binding protein that plays a role in determining RNA stability (440 aa)
           
  0.483
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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