node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC3 | YKR011C | YLR314C | YKR011C | Cell division control protein 3; Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress. | 0.430 |
EGO4 | RGI1 | YNR034W-A | YER067W | Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication. | Respiratory growth induced protein 1; Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog, RGI2, that arose from the whole genome duplication. | 0.698 |
EGO4 | UIP3 | YNR034W-A | YAR027W | Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication. | ULP1-interacting protein 3; Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family; Belongs to the DUP/COS family. | 0.412 |
EGO4 | YKR011C | YNR034W-A | YKR011C | Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication. | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress. | 0.419 |
LCL1 | SET3 | YPL056C | YKR029C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | 0.412 |
LCL1 | YDR222W | YPL056C | YDR222W | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | SVF1-like protein YDR222W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication; Belongs to the SVF1 family. | 0.480 |
LCL1 | YKR011C | YPL056C | YKR011C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress. | 0.471 |
LCL1 | YOR343C | YPL056C | YOR343C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Uncharacterized protein YOR343C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.649 |
LCL1 | YPR003C | YPL056C | YPR003C | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.510 |
RGI1 | EGO4 | YER067W | YNR034W-A | Respiratory growth induced protein 1; Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog, RGI2, that arose from the whole genome duplication. | Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication. | 0.698 |
RGI1 | YKR011C | YER067W | YKR011C | Respiratory growth induced protein 1; Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog, RGI2, that arose from the whole genome duplication. | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress. | 0.422 |
SDD4 | SET3 | YPR022C | YKR029C | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | 0.402 |
SDD4 | YKR011C | YPR022C | YKR011C | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress. | 0.413 |
SDD4 | YPR003C | YPR022C | YPR003C | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.437 |
SET3 | LCL1 | YKR029C | YPL056C | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan. | 0.412 |
SET3 | SDD4 | YKR029C | YPR022C | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P. | 0.402 |
SET3 | YDR222W | YKR029C | YDR222W | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | SVF1-like protein YDR222W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication; Belongs to the SVF1 family. | 0.443 |
SET3 | YKR011C | YKR029C | YKR011C | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress. | 0.429 |
SET3 | YPR003C | YKR029C | YPR003C | Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication. | Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. | 0.451 |
UIP3 | EGO4 | YAR027W | YNR034W-A | ULP1-interacting protein 3; Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family; Belongs to the DUP/COS family. | Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication. | 0.412 |