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GEX2 protein (Saccharomyces cerevisiae) - STRING interaction network
"GEX2" - Proton:glutathione antiporter localized to the vacuolar and plasma membranes in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GEX2Proton-glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway; Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway (615 aa)    
Predicted Functional Partners:
AMF1
Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug-H+ antiporters; YOR378W is not an essential gene; Probable ATP-dependent export permease involved in drug resistance through pumping them out of the cell (515 aa)
           
  0.678
YMR279C
Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; paralo /.../he efflux pump ATR1 (540 aa)
           
  0.637
VBA4
Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene; Transporter required for vacuolar uptake of basic amino acids (768 aa)
           
  0.620
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) (699 aa)
   
 
  0.540
VBA2
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine, arginine and lysine and to a lesser extent tyrosine (474 aa)
           
  0.540
PHA2
Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway (334 aa)
         
  0.525
VBA3
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of histidine and lysine (458 aa)
     
   
  0.522
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny; Transporter required for vacuolar uptake of basic amino acids (582 aa)
     
   
  0.518
VBA1
Permease of basic amino acids in the vacuolar membrane; Transporter required for vacuolar uptake of at least histidine and lysine (562 aa)
           
  0.517
GEX1
Proton-glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; Proton/glutathione antiporter that imports glutathione from the vacuole and exports it through the plasma membrane. Involved in resistance to oxidative stress and modulation of the PKA pathway (615 aa)
     
   
0.514
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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