node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DPS1 | SOF1 | YLL018C | YLL011W | Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. | Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; Belongs to the WD repeat DCAF13/WDSOF1 family. | 0.490 |
DPS1 | SPO75 | YLL018C | YLL005C | Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | 0.475 |
FSH1 | SPO75 | YHR049W | YLL005C | Family of serine hydrolases 1; Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2. | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | 0.449 |
FSH1 | SPS2 | YHR049W | YDR522C | Family of serine hydrolases 1; Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2. | Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component. | 0.402 |
GAS2 | SPO75 | YLR343W | YLL005C | 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | 0.487 |
GAS2 | SPR1 | YLR343W | YOR190W | 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 (cellulase A) family. | 0.624 |
GAS2 | SPS1 | YLR343W | YDR523C | 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. | Sporulation-specific protein 1; Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis. | 0.517 |
GAS2 | SPS2 | YLR343W | YDR522C | 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. | Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component. | 0.640 |
MSC6 | SPO75 | YOR354C | YLL005C | Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids. | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | 0.517 |
SOF1 | DPS1 | YLL011W | YLL018C | Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; Belongs to the WD repeat DCAF13/WDSOF1 family. | Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. | 0.490 |
SOF1 | SPO75 | YLL011W | YLL005C | Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; Belongs to the WD repeat DCAF13/WDSOF1 family. | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | 0.444 |
SPO75 | DPS1 | YLL005C | YLL018C | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. | 0.475 |
SPO75 | FSH1 | YLL005C | YHR049W | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Family of serine hydrolases 1; Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2. | 0.449 |
SPO75 | GAS2 | YLL005C | YLR343W | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | 1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family. | 0.487 |
SPO75 | MSC6 | YLL005C | YOR354C | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids. | 0.517 |
SPO75 | SOF1 | YLL005C | YLL011W | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; Belongs to the WD repeat DCAF13/WDSOF1 family. | 0.444 |
SPO75 | SPR1 | YLL005C | YOR190W | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 (cellulase A) family. | 0.445 |
SPO75 | SPS1 | YLL005C | YDR523C | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Sporulation-specific protein 1; Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis. | 0.453 |
SPO75 | SPS2 | YLL005C | YDR522C | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component. | 0.528 |
SPO75 | YFL067W | YLL005C | YFL067W | Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family. | Uncharacterized membrane protein YFL067W; Protein of unknown function; down-regulated at low calcium levels; mCherry fusion protein localizes to the vacuole. | 0.696 |