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EMC6 protein (Saccharomyces cerevisiae) - STRING interaction network
"EMC6" - Member of a transmembrane complex required for efficient folding of proteins in the ER in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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Score
EMC6Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (108 aa)    
Predicted Functional Partners:
EMC2
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (292 aa)
       
  0.998
EMC3
Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (253 aa)
     
  0.995
EMC1
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (760 aa)
       
  0.994
EMC4
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (190 aa)
     
  0.986
EMC5
Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) (141 aa)
       
  0.980
IZH3
Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels (543 aa)
       
      0.673
EMC10
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein (205 aa)
           
  0.622
EMP65
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins; May be involved in membrane protein folding (556 aa)
           
  0.575
LAM6
Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene; Involved in regulation of various organellar membrane contact sites (PubMed-26119743). May be involved in sterol transfer between intracellular membranes (PubMed-26001273). Selectively transports sterols between membranes in vitro. Involved in stress-dependent formation of sterol-enriched vacuolar membrane domains (PubMed-25987606) (693 aa)
           
  0.489
LCL2
Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); Probable component of the endoplasmic reticulum- associated degradation (ERAD) pathway that acts upstream of HRD3 and USA1 (131 aa)
           
  0.489
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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