STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RRT7Regulator of rDNA transcription protein 7; Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription. (113 aa)    
Predicted Functional Partners:
CSC1
Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1.
      
 0.877
YLL032C
KH domain-containing protein YLL032C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene.
   
  
 0.873
GPI13
GPI ethanolamine phosphate transferase 3; ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein.
      
 0.805
IRC19
Increased recombination centers protein 19; Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci.
   
  
 0.756
YLL037W
Putative uncharacterized protein YLL037W; Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor.
   
  
 0.712
YDR433W
Putative uncharacterized protein YDR433W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.
      
 0.700
PNG1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease; Belongs to the transglutaminase-like superfamily. PNGase family.
      
 0.551
FRA1
Putative Xaa-Pro aminopeptidase FRA1; Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Belongs to the peptidase M24B family.
      
 0.536
DTR1
Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation.
   
  
 0.522
YBL108W
Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family.
   
    0.463
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: ATCC 18824, Candida robusta, Mycoderma cerevisiae, NRRL Y-12632, S. cerevisiae, Saccharomyces capensis, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, yeast
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