node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MET10 | MET14 | YFR030W | YKL001C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | 0.994 |
MET10 | MET2 | YFR030W | YNL277W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfamily. MetX family. | 0.905 |
MET10 | MET32 | YFR030W | YDR253C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Transcriptional regulator MET32; Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication. | 0.678 |
MET10 | MHT1 | YFR030W | YLL062C | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Homocysteine S-methyltransferase 1; S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. | 0.633 |
MET10 | MMP1 | YFR030W | YLL061W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. | 0.502 |
MET10 | MUP3 | YFR030W | YHL036W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Low affinity methionine permease; similar to Mup1p. | 0.402 |
MET10 | SAM1 | YFR030W | YLR180W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | S-adenosylmethionine synthase 1; S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication. | 0.631 |
MET10 | YLL058W | YFR030W | YLL058W | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene. | 0.935 |
MET14 | MET10 | YKL001C | YFR030W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | 0.994 |
MET14 | MET2 | YKL001C | YNL277W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfamily. MetX family. | 0.914 |
MET14 | MET32 | YKL001C | YDR253C | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Transcriptional regulator MET32; Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication. | 0.951 |
MET14 | MHT1 | YKL001C | YLL062C | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Homocysteine S-methyltransferase 1; S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. | 0.590 |
MET14 | MMP1 | YKL001C | YLL061W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. | 0.554 |
MET14 | MUP1 | YKL001C | YGR055W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; To yeast low affinity methionine permease (MUP3). | 0.480 |
MET14 | MUP3 | YKL001C | YHL036W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Low affinity methionine permease; similar to Mup1p. | 0.424 |
MET14 | SAM1 | YKL001C | YLR180W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | S-adenosylmethionine synthase 1; S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication. | 0.723 |
MET14 | YLL058W | YKL001C | YLL058W | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene. | 0.585 |
MET2 | MET10 | YNL277W | YFR030W | L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfamily. MetX family. | Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide. | 0.905 |
MET2 | MET14 | YNL277W | YKL001C | L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfamily. MetX family. | Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant. | 0.914 |
MET2 | MET32 | YNL277W | YDR253C | L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfamily. MetX family. | Transcriptional regulator MET32; Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication. | 0.749 |