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THI73 protein (Saccharomyces cerevisiae) - STRING interaction network
"THI73" - Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine in Saccharomyces cerevisiae
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Predicted Interactions
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textmining
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protein homology
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THI73Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway (523 aa)    
Predicted Functional Partners:
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p; Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression. The methyltransferase activity requires the recruitment to the RNA polymerase II, which is CTK1 dependent (733 aa)
       
      0.594
YNL089C
Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins (158 aa)
           
  0.580
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport; Probable transporter. Does not act in the transport of monocarboxylic acids across the plasma membrane (501 aa)
           
  0.579
THI7
Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia; Responsible for intake of thiamine (598 aa)
           
  0.540
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity; High-affinity pH-dependent nicotinamide riboside transporter which also transports thiamine with low affinity. Involved in 5-fluorocytosine sensitivity (598 aa)
           
  0.511
NRK1
Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN) (240 aa)
           
  0.487
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p; Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins (599 aa)
           
  0.483
YOL079W
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data (132 aa)
           
  0.470
YHR078W
High osmolarity-regulated gene of unknown function (552 aa)
           
  0.470
BNA1
3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (177 aa)
           
  0.443
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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