| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EMC6 | IZH3 | YLL014W | YLR023C | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.619 |
| EMC6 | ZAP1 | YLL014W | YJL056C | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93. | Zinc-responsive transcriptional regulator ZAP1; Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains. | 0.420 |
| FET3 | IZH3 | YMR058W | YLR023C | Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.516 |
| FET3 | IZH4 | YMR058W | YOL101C | Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress. | ADIPOR-like receptor IZH4; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication. | 0.470 |
| FET3 | SCS7 | YMR058W | YMR272C | Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress. | Ceramide very long chain fatty acid hydroxylase SCS7; Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; Belongs to the sterol desaturase family. SCS7 subfamily. | 0.449 |
| FET3 | ZAP1 | YMR058W | YJL056C | Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress. | Zinc-responsive transcriptional regulator ZAP1; Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains. | 0.452 |
| FMP30 | IZH3 | YPL103C | YLR023C | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial; Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D; Belongs to the NAPE-PLD family. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.555 |
| FOL2 | INA1 | YGR267C | YLR413W | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.480 |
| FOL2 | IZH3 | YGR267C | YLR023C | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.731 |
| FOL2 | IZH4 | YGR267C | YOL101C | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant. | ADIPOR-like receptor IZH4; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication. | 0.466 |
| INA1 | FOL2 | YLR413W | YGR267C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant. | 0.480 |
| INA1 | IZH3 | YLR413W | YLR023C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.536 |
| INA1 | IZH4 | YLR413W | YOL101C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | ADIPOR-like receptor IZH4; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication. | 0.446 |
| INA1 | MPD2 | YLR413W | YOL088C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p. | 0.510 |
| INA1 | YOR012W | YLR413W | YOR012W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Uncharacterized protein YOR012W; Putative protein of unknown function. | 0.538 |
| IZH3 | EMC6 | YLR023C | YLL014W | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93. | 0.619 |
| IZH3 | FET3 | YLR023C | YMR058W | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress. | 0.516 |
| IZH3 | FMP30 | YLR023C | YPL103C | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial; Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D; Belongs to the NAPE-PLD family. | 0.555 |
| IZH3 | FOL2 | YLR023C | YGR267C | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant. | 0.731 |
| IZH3 | INA1 | YLR023C | YLR413W | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.536 |
STRING v12.5 is now available!
