PET309 protein (Saccharomyces cerevisiae) - STRING interaction network
"PET309" - Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts in Saccharomyces cerevisiae
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Predicted Interactions
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Gene Fusion
PET309Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs); Required for initiation of translation of the COX1 coding region. Also involved in the stability of the intron containing transcript of COX1 (965 aa)    
Predicted Functional Partners:
Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane; Required for translation of the mitochondrial gene for cytochrome c oxidase subunit II (COX2) (800 aa)
Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription; Required for the processing and/or for the stability of the CYTB and COX1 intron-containing pre-mRNAs and of the ATP6 transcript. Could be a stem-loop RNA-binding protein that plays a role in determining RNA stability (440 aa)
Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (534 aa)
Mitochondrial inner membrane protein; binds to the 5’ UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; Activator of specific mitochondrial mRNAs. PET54 is involved in the excision of intron aI5-beta from pre-mRNA for cytochrome c oxidase I (COX1) and plays a role in promoting the translation of COX3 (293 aa)
Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (300 aa)
Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane; Required for expression of the mitochondrial gene for cytochrome c oxidase subunit 3 (COX3). PET122 seems to work by directly interacting with the small ribosomal subunit to promote translation initiation on the COX3 mRNA (254 aa)
Mitochondrial protein that interacts with the 5’-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p; Responsible for conferring a stable 5’-end on cytochrome b mRNA (654 aa)
Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step that couples MSS51-COX14-dependent regulation of COX1 translation to early steps of cytochrome c oxidase assembly (389 aa)
Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; Has a dual role in the assembly of cytochrome oxidase subunit 1 (COX1). It has a regulative function on COX1 synthesis, acting as a translational activator specific for the COX1 mRNA, and it also binds to newly synthesized COX1 protein. Together with COX14, may act as a chaperone that binds efficiently unassembled COX1 and prevents it from unproductive aggregatio [...] (436 aa)
Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits (398 aa)
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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