node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG18 | GIS3 | YFR021W | YLR094C | Autophagy-related protein 18; Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. | Protein of unknown function. | 0.486 |
GIS2 | GIS3 | YNL255C | YLR094C | Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2. | Protein of unknown function. | 0.510 |
GIS2 | GIS4 | YNL255C | YML006C | Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2. | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. | 0.549 |
GIS2 | RPS22A | YNL255C | YJL190C | Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2. | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication. | 0.524 |
GIS3 | ATG18 | YLR094C | YFR021W | Protein of unknown function. | Autophagy-related protein 18; Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. | 0.486 |
GIS3 | GIS2 | YLR094C | YNL255C | Protein of unknown function. | Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2. | 0.510 |
GIS3 | GIS4 | YLR094C | YML006C | Protein of unknown function. | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. | 0.802 |
GIS3 | OLA1 | YLR094C | YBR025C | Protein of unknown function. | Obg-like ATPase 1; P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. | 0.609 |
GIS3 | PDE2 | YLR094C | YOR360C | Protein of unknown function. | 3',5'-cyclic-nucleotide phosphodiesterase 2; High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon. | 0.493 |
GIS3 | PML39 | YLR094C | YML107C | Protein of unknown function. | Pre-mRNA leakage protein 39; Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes. | 0.418 |
GIS3 | RPS22A | YLR094C | YJL190C | Protein of unknown function. | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication. | 0.515 |
GIS3 | SGE1 | YLR094C | YPR198W | Protein of unknown function. | Protein SGE1; Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations. | 0.552 |
GIS3 | SSN8 | YLR094C | YNL025C | Protein of unknown function. | Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C. | 0.501 |
GIS3 | TUB3 | YLR094C | YML124C | Protein of unknown function. | Tubulin alpha-3 chain; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication. | 0.470 |
GIS4 | GIS2 | YML006C | YNL255C | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. | Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2. | 0.549 |
GIS4 | GIS3 | YML006C | YLR094C | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. | Protein of unknown function. | 0.802 |
GIS4 | SGE1 | YML006C | YPR198W | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. | Protein SGE1; Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations. | 0.404 |
GIS4 | SSN8 | YML006C | YNL025C | Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway. | Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C. | 0.417 |
OLA1 | GIS3 | YBR025C | YLR094C | Obg-like ATPase 1; P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. | Protein of unknown function. | 0.609 |
OLA1 | RPS22A | YBR025C | YJL190C | Obg-like ATPase 1; P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication. | 0.650 |