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CHA4 protein (Saccharomyces cerevisiae) - STRING interaction network
"CHA4" - DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine in Saccharomyces cerevisiae
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Predicted Interactions
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CHA4DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain; Activates the CHA1 gene for L-serine dehydratase. Binds to the DNA sequence 5’-GVGGARAYRTRATTCCRC-3’ (648 aa)    
Predicted Functional Partners:
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine (360 aa)
           
  0.816
ILV1
Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation (576 aa)
       
 
  0.709
STB4
Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; Binds to SIN3 (949 aa)
       
 
  0.611
PUT3
Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitog /.../rces; has a Zn(2)-Cys(6) binuclear cluster domain; Positive activator of the proline utilization pathway. Binds to the promoters of PUT1 and PUT2 genes. Recognizes and binds to the DNA sequence 5’-CGG-N(10)-CCG-3’ (979 aa)
           
  0.575
LEU3
Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis; Factor for control of RNA levels of a group of leucine- specific genes (886 aa)
           
  0.520
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; Involved in cell surface assembly and regulation of the gene related to flocculation (asexual cell aggregation). Mutations in SFL1 causes constitutive cell aggregation (766 aa)
       
      0.507
ARO80
Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids; Transcription activator required for the expression of genes involved in the catabolism of aromatic amino acids such as the aromatic aminotransferase II ARO9 and the phenylpyruvate decarboxylase ARO10 (950 aa)
           
  0.446
DAL81
Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism; Positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2), urea (DUR1 and DUR2), arginine and allantoin (970 aa)
           
  0.418
UGA3
Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; GABA-dependent positive regulation of genes required for catabolism of GABA (UGA4, UGA1, and UGA2) (528 aa)
           
  0.418
GAL4
DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p; This protein is a positive regulator for the gene expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10, and MEL1 which code for the enzymes used to convert galactose to glucose. It recognizes a 17 base pair sequence in (5’-CGGRNNRCYNYNCNCCG-3’) the upstream activating sequence (UAS-G) of these genes (881 aa)
           
  0.418
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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