| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ISW1 | YLR149C | YBR245C | YLR149C | ISWI chromatin-remodeling complex ATPase ISW1; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK. | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | 0.470 |
| ISW1 | YLR152C | YBR245C | YLR152C | ISWI chromatin-remodeling complex ATPase ISW1; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.457 |
| MAE1 | YLR152C | YKL029C | YLR152C | Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.577 |
| MEK1 | YLR152C | YOR351C | YLR152C | Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.519 |
| PCD1 | SRL2 | YLR151C | YLR082C | Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1. | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | 0.540 |
| PCD1 | YLR149C | YLR151C | YLR149C | Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1. | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | 0.611 |
| PCD1 | YLR152C | YLR151C | YLR152C | Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.604 |
| RNH203 | SRL2 | YLR154C | YLR082C | Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome. | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | 0.511 |
| RNH203 | YLR152C | YLR154C | YLR152C | Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.635 |
| RRT15 | YLR152C | YLR162W-A | YLR152C | Regulator of rDNA transcription protein 15; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.536 |
| SRL2 | PCD1 | YLR082C | YLR151C | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1. | 0.540 |
| SRL2 | RNH203 | YLR082C | YLR154C | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome. | 0.511 |
| SRL2 | YLR149C | YLR082C | YLR149C | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | 0.653 |
| SRL2 | YLR152C | YLR082C | YLR152C | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.840 |
| TDA8 | YLR152C | YAL064C-A | YLR152C | Topoisomerase I damage affected protein 8; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.884 |
| YLR149C | ISW1 | YLR149C | YBR245C | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | ISWI chromatin-remodeling complex ATPase ISW1; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK. | 0.470 |
| YLR149C | PCD1 | YLR149C | YLR151C | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1. | 0.611 |
| YLR149C | SRL2 | YLR149C | YLR082C | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation. | 0.653 |
| YLR149C | YLR152C | YLR149C | YLR152C | Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress. | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | 0.776 |
| YLR152C | ISW1 | YLR152C | YBR245C | Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene. | ISWI chromatin-remodeling complex ATPase ISW1; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK. | 0.457 |
