node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAT1 | AAT2 | YKL106W | YLR027C | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.978 |
AAT1 | ADE12 | YKL106W | YNL220W | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence. | 0.932 |
AAT1 | ARG1 | YKL106W | YOL058W | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Argininosuccinate synthase; Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate. | 0.926 |
AAT1 | ASN1 | YKL106W | YPR145W | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication. | 0.973 |
AAT1 | ASN2 | YKL106W | YGR124W | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication. | 0.954 |
AAT1 | ASP1 | YKL106W | YDR321W | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively. | 0.925 |
AAT1 | ASP3-1 | YKL106W | YLR155C | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-1 has a paralog, ASP3-3, that arose from a segmental duplication. | 0.922 |
AAT1 | URA2 | YKL106W | YJL130C | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | Glutamine-dependent carbamoyl-phosphate synthase; Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. | 0.937 |
AAT2 | AAT1 | YLR027C | YKL106W | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | 0.978 |
AAT2 | ADE12 | YLR027C | YNL220W | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence. | 0.933 |
AAT2 | ARG1 | YLR027C | YOL058W | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Argininosuccinate synthase; Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate. | 0.935 |
AAT2 | ASN1 | YLR027C | YPR145W | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication. | 0.957 |
AAT2 | ASN2 | YLR027C | YGR124W | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication. | 0.962 |
AAT2 | ASP1 | YLR027C | YDR321W | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively. | 0.939 |
AAT2 | ASP3-1 | YLR027C | YLR155C | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-1 has a paralog, ASP3-3, that arose from a segmental duplication. | 0.950 |
AAT2 | ASP3-2 | YLR027C | YLR157C | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication. | 0.534 |
AAT2 | ASP3-3 | YLR027C | YLR158C | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication. | 0.531 |
AAT2 | URA2 | YLR027C | YJL130C | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Glutamine-dependent carbamoyl-phosphate synthase; Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. | 0.925 |
ADE12 | AAT1 | YNL220W | YKL106W | Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence. | Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis. | 0.932 |
ADE12 | AAT2 | YNL220W | YLR027C | Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence. | Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | 0.933 |