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THI7 protein (Saccharomyces cerevisiae) - STRING interaction network
"THI7" - Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters in Saccharomyces cerevisiae
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Predicted Interactions
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THI7Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia; Responsible for intake of thiamine (598 aa)    
Predicted Functional Partners:
THI3
Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis; One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6, ARO10, and THI3) involved in amino acid catabolism. The enzyme catalyzes the decarboxylation of amino acids, which, in a first step, have been transaminated to the corresponding 2-oxo acids (alpha-keto-acids). In a third step, the resulting aldehydes are reduced to alcohols, collectively referred to as fusel oils or alcohols. Its prefer [...] (609 aa)
       
 
  0.814
PDC2
Putative transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; mutant fails to grow on 2% glucose and thus is scored as inviab /.../er standard conditions; Essential for the synthesis of pyruvate decarboxylase. May be important for a high basal level of PDC gene expression or play a positive role in the autoregulation control of PDC1 and PDC5 (925 aa)
       
 
  0.783
THI80
Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate); Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP) (319 aa)
           
  0.680
THI74
Mitochondrial transporter repressible by thiamine; May be involved in thiaminediphosphate transport across the mitochondrial membrane (370 aa)
           
  0.622
THI4
Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a sing /.../nover only; required for mitochondrial genome stability in response to DNA damaging agents; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction incl [...] (326 aa)
           
  0.621
THI2
Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate d /.../ possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type; Positive regulator of thiamine biosynthesis (450 aa)
       
 
  0.599
THI11
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme (340 aa)
           
  0.572
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p; Low affinity thiamine transporter responsible for intake of thiamine. It is possible that the primary function is the uptake of closely related compounds and that thiamine transport is a secondary activity of these proteins (599 aa)
   
 
0.561
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs; Transports either thiamine or, rather, a related metabolite involved in the thiamine biosynthesis pathway (523 aa)
           
  0.540
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity; High-affinity pH-dependent nicotinamide riboside transporter which also transports thiamine with low affinity. Involved in 5-fluorocytosine sensitivity (598 aa)
   
 
 
0.532
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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