| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSC1 | DSK2 | YLR241W | YMR276W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress. | 0.532 |
| CSC1 | DTR1 | YLR241W | YBR180W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation. | 0.599 |
| CSC1 | GDB1 | YLR241W | YPR184W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Amylo-alpha-1,6-glucosidase; Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress. | 0.903 |
| CSC1 | MSS11 | YLR241W | YMR164C | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Transcription activator MSS11; Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1. | 0.479 |
| CSC1 | PPG1 | YLR241W | YNR032W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Serine/threonine-protein phosphatase PP2A-like PPG1; Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases. | 0.519 |
| CSC1 | RAD23 | YLR241W | YEL037C | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | UV excision repair protein RAD23; Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage. | 0.475 |
| CSC1 | RFX1 | YLR241W | YLR176C | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | RFX-like DNA-binding protein RFX1; Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins. | 0.497 |
| CSC1 | RRT7 | YLR241W | YLL030C | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Regulator of rDNA transcription protein 7; Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription. | 0.877 |
| CSC1 | SPC98 | YLR241W | YNL126W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Spindle pole body component SPC98; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque. | 0.535 |
| CSC1 | YDR433W | YLR241W | YDR433W | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | Putative uncharacterized protein YDR433W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.791 |
| DSK2 | CSC1 | YMR276W | YLR241W | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress. | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | 0.532 |
| DSK2 | MSS11 | YMR276W | YMR164C | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress. | Transcription activator MSS11; Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1. | 0.432 |
| DSK2 | RAD23 | YMR276W | YEL037C | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress. | UV excision repair protein RAD23; Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage. | 0.996 |
| DSK2 | YDR433W | YMR276W | YDR433W | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress. | Putative uncharacterized protein YDR433W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data. | 0.559 |
| DTR1 | CSC1 | YBR180W | YLR241W | Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation. | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | 0.599 |
| DTR1 | RRT7 | YBR180W | YLL030C | Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation. | Regulator of rDNA transcription protein 7; Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription. | 0.522 |
| GDB1 | CSC1 | YPR184W | YLR241W | Amylo-alpha-1,6-glucosidase; Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress. | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | 0.903 |
| MSS11 | CSC1 | YMR164C | YLR241W | Transcription activator MSS11; Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1. | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | 0.479 |
| MSS11 | DSK2 | YMR164C | YMR276W | Transcription activator MSS11; Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1. | Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress. | 0.432 |
| PPG1 | CSC1 | YNR032W | YLR241W | Serine/threonine-protein phosphatase PP2A-like PPG1; Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases. | Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1. | 0.519 |