| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GDH2 | GLT1 | YDL215C | YDL171C | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | 0.997 |
| GDH2 | YLR257W | YDL215C | YLR257W | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.839 |
| GLT1 | GDH2 | YDL171C | YDL215C | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | 0.997 |
| GLT1 | YGR125W | YDL171C | YGR125W | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.433 |
| GLT1 | YLR257W | YDL171C | YLR257W | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.940 |
| SOL2 | YLR257W | YCR073W-A | YLR257W | 6-phosphogluconolactonase-like protein 2; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.623 |
| SSA2 | YLR257W | YLL024C | YLR257W | Heat shock protein SSA2; HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.535 |
| UGX2 | YGR125W | YDL169C | YGR125W | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.582 |
| UGX2 | YLR257W | YDL169C | YLR257W | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.559 |
| YGR017W | YLR257W | YGR017W | YLR257W | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.749 |
| YGR017W | YMR295C | YGR017W | YMR295C | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | Uncharacterized protein YMR295C; Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication. | 0.696 |
| YGR125W | GLT1 | YGR125W | YDL171C | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | 0.433 |
| YGR125W | UGX2 | YGR125W | YDL169C | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | 0.582 |
| YGR125W | YLR257W | YGR125W | YLR257W | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.549 |
| YLR257W | GDH2 | YLR257W | YDL215C | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | 0.839 |
| YLR257W | GLT1 | YLR257W | YDL171C | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | 0.940 |
| YLR257W | SOL2 | YLR257W | YCR073W-A | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 6-phosphogluconolactonase-like protein 2; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication. | 0.623 |
| YLR257W | SSA2 | YLR257W | YLL024C | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | Heat shock protein SSA2; HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation. | 0.535 |
| YLR257W | UGX2 | YLR257W | YDL169C | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | 0.559 |
| YLR257W | YGR017W | YLR257W | YGR017W | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | 0.749 |
