node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GDH2 | GLT1 | YDL215C | YDL171C | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | 0.993 |
GDH2 | YLR257W | YDL215C | YLR257W | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.560 |
GLT1 | GDH2 | YDL171C | YDL215C | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | 0.993 |
GLT1 | YGR125W | YDL171C | YGR125W | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.465 |
GLT1 | YLR257W | YDL171C | YLR257W | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.579 |
SPT21 | YGR017W | YMR179W | YGR017W | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress. | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | 0.656 |
SPT21 | YLR257W | YMR179W | YLR257W | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.514 |
SPT21 | YMR295C | YMR179W | YMR295C | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress. | Uncharacterized protein YMR295C; Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication. | 0.447 |
UGX2 | YGR125W | YDL169C | YGR125W | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | 0.605 |
UGX2 | YLR257W | YDL169C | YLR257W | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.555 |
YGR017W | SPT21 | YGR017W | YMR179W | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress. | 0.656 |
YGR017W | YLR257W | YGR017W | YLR257W | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.755 |
YGR017W | YMR295C | YGR017W | YMR295C | Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm. | Uncharacterized protein YMR295C; Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication. | 0.713 |
YGR125W | GLT1 | YGR125W | YDL171C | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | 0.465 |
YGR125W | UGX2 | YGR125W | YDL169C | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | Protein of unknown function; transcript accumulates in response to any combination of stress conditions. | 0.605 |
YGR125W | YLR257W | YGR125W | YLR257W | Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.558 |
YHR131C | YLR257W | YHR131C | YLR257W | PH domain-containing protein YHR131C; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication. | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | 0.537 |
YLR257W | GDH2 | YLR257W | YDL215C | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis. | 0.560 |
YLR257W | GLT1 | YLR257W | YDL171C | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions. | 0.579 |
YLR257W | SPT21 | YLR257W | YMR179W | Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress. | Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress. | 0.514 |