node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COS111 | INA1 | YBR203W | YLR413W | F-box protein COS111; Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.511 |
COS111 | IZH1 | YBR203W | YDR492W | F-box protein COS111; Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | 0.403 |
FAA4 | INA1 | YMR246W | YLR413W | Long-chain-fatty-acid--CoA ligase 4; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4; Belongs to the ATP-dependent AMP-binding enzyme family. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.576 |
FRT1 | INA1 | YOR324C | YLR413W | Protein HPH1; Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.616 |
INA1 | COS111 | YLR413W | YBR203W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | F-box protein COS111; Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.511 |
INA1 | FAA4 | YLR413W | YMR246W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Long-chain-fatty-acid--CoA ligase 4; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.576 |
INA1 | FRT1 | YLR413W | YOR324C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Protein HPH1; Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication. | 0.616 |
INA1 | IZH1 | YLR413W | YDR492W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | 0.633 |
INA1 | IZH3 | YLR413W | YLR023C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.536 |
INA1 | MPD2 | YLR413W | YOL088C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p. | 0.510 |
INA1 | SHE2 | YLR413W | YKL130C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | SWI5-dependent HO expression protein 2; RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER. | 0.640 |
INA1 | TCB3 | YLR413W | YML072C | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Tricalbin-3; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; Belongs to the tricalbin family. | 0.672 |
INA1 | YBL081W | YLR413W | YBL081W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Uncharacterized protein YBL081W; Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport. | 0.576 |
INA1 | YOR012W | YLR413W | YOR012W | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | Uncharacterized protein YOR012W; Putative protein of unknown function. | 0.538 |
IZH1 | COS111 | YDR492W | YBR203W | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | F-box protein COS111; Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.403 |
IZH1 | INA1 | YDR492W | YLR413W | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.633 |
IZH1 | IZH3 | YDR492W | YLR023C | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | 0.512 |
IZH1 | YOR012W | YDR492W | YOR012W | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | Uncharacterized protein YOR012W; Putative protein of unknown function. | 0.416 |
IZH3 | INA1 | YLR023C | YLR413W | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication. | 0.536 |
IZH3 | IZH1 | YLR023C | YDR492W | ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family. | ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication. | 0.512 |