node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEM1 | TDA5 | YER061C | YLR426W | 3-oxoacyl-[acyl-carrier-protein] synthase homolog; Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.566 |
COS7 | TDA5 | YDL248W | YLR426W | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.616 |
OCA1 | OCA2 | YNL099C | YNL056W | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene. | 0.998 |
OCA1 | TDA5 | YNL099C | YLR426W | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.585 |
OCA1 | YAH1 | YNL099C | YPL252C | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | Adrenodoxin homolog, mitochondrial; Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1; Belongs to the adrenodoxin/putidaredoxin family. | 0.664 |
OCA1 | YGL242C | YNL099C | YGL242C | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.548 |
OCA2 | OCA1 | YNL056W | YNL099C | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene. | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | 0.998 |
OCA2 | TDA5 | YNL056W | YLR426W | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene. | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.531 |
OCA2 | YAH1 | YNL056W | YPL252C | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene. | Adrenodoxin homolog, mitochondrial; Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1; Belongs to the adrenodoxin/putidaredoxin family. | 0.664 |
OCA2 | YGL242C | YNL056W | YGL242C | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.495 |
PAU23 | TDA5 | YLR037C | YLR426W | Seripauperin-23; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family. Seripauperin subfamily. | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.543 |
PAU23 | YGL242C | YLR037C | YGL242C | Seripauperin-23; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family. Seripauperin subfamily. | Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable. | 0.492 |
TDA5 | CEM1 | YLR426W | YER061C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 3-oxoacyl-[acyl-carrier-protein] synthase homolog; Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.566 |
TDA5 | COS7 | YLR426W | YDL248W | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies. | 0.616 |
TDA5 | OCA1 | YLR426W | YNL099C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA. | 0.585 |
TDA5 | OCA2 | YLR426W | YNL056W | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene. | 0.531 |
TDA5 | PAU23 | YLR426W | YLR037C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Seripauperin-23; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family. Seripauperin subfamily. | 0.543 |
TDA5 | TMS1 | YLR426W | YDR105C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance. | 0.539 |
TDA5 | VMA6 | YLR426W | YLR447C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits. | 0.534 |
TDA5 | XRS2 | YLR426W | YDR369C | Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling. | 0.596 |