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CAR2 protein (Saccharomyces cerevisiae) - STRING interaction network
"CAR2" - L-ornithine transaminase in Saccharomyces cerevisiae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
CAR2L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive (424 aa)    
Predicted Functional Partners:
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance (333 aa)
 
  0.999
ARG3
Ornithine carbamoyltransferase; also known as carbamoylphosphate-L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline (338 aa)
 
 
  0.996
PUT2
Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism (575 aa)
 
  0.991
PRO2
Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis; Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (456 aa)
   
  0.986
PRO1
Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis; Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (428 aa)
     
  0.984
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p (863 aa)
   
 
  0.982
YHR033W
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm (423 aa)
       
  0.972
SPE1
Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation (466 aa)
   
 
  0.962
ARG7
Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis- the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate (441 aa)
   
  0.942
ARG4
Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway (463 aa)
   
 
  0.906
Your Current Organism:
Saccharomyces cerevisiae
NCBI taxonomy Id: 4932
Other names: Candida robusta, Pachytichospora, S. cerevisiae, Saccharomyces, Saccharomyces capensis, Saccharomyces cerevisiae, Saccharomyces italicus, Saccharomyces oviformis, Saccharomyces uvarum var. melibiosus, lager beer yeast, yeast
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